Candidiasis in Interferon- Knockout (IFN- -/-) Mice
نویسندگان
چکیده
منابع مشابه
Pathology of sarcocystis neurona in interferon-gamma gene knockout mice.
Pathologic changes were studied in 27 interferon-gamma gene knockout mice 34-54 days after being fed graded doses of Sarcocystis neurona sporocysts derived from a naturally infected opossum. The target tissue for S. neurona infection was the central nervous system. Characteristic histopathologic changes present in all mice consisted of an inflammatory infiltrate consisting of mostly neutrophils...
متن کاملIntrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice.
We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acutely infected GKO mice exhibited dramatically elevated numbers of CFU in lungs...
متن کاملThe Gamma Interferon (IFN- ) Mimetic Peptide IFN- (95-133) Prevents Encephalomyocarditis Virus Infection both in Tissue Culture and in Mice
The Gamma Interferon (IFN) Mimetic Peptide IFN(95-133) Prevents Encephalomyocarditis Virus Infection both in Tissue Culture and in Mice Mustafa G. Mujtaba,* Chintak B. Patel, Ravi A. Patel, Lawrence O. Flowers, Marjorie A. Burkhart, Lilian W. Waiboci, James Martin, Mohammad I. Haider, Chulbul M. Ahmed, and Howard M. Johnson Department of Microbiology and Cell Science, University of Florida, Gai...
متن کاملEarly resistance of interleukin-10 knockout mice to acute systemic candidiasis.
In contrast to immunocompetent controls, interleukin-10 (IL-10) knockout (KO) mice eliminated an experimental intravenous inoculation with Candida albicans from their kidneys. Improved clearance of C. albicans from the kidneys of IL-10 KO mice was evident at 24 h after intravenous challenge with the fungus. Conversely, mice with a deletion of the IL-4 cytokine gene were more susceptible to syst...
متن کاملDeterioration of visual function as examined by electroretinograms in Toxoplasma gondii-infected IFN-gamma-knockout mice.
PURPOSE To investigate by ERG the effects of Toxoplasma gondii infection on the visual function of interferon gamma knockout (GKO) mice, as a model of immunocompromised hosts. METHODS Susceptible wild-type (WT) C57BL/6 and GKO C57BL/6 mice were infected with five cysts of the avirulent T. gondii perorally. ERGs were recorded before and after the infection. The eyes of WT and GKO mice were enu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 1998
ISSN: 0022-1899,1537-6613
DOI: 10.1086/515645